LB931 Examining real-world treatment patterns of locally advanced basal cell carcinomas

Locally advanced basal cell carcinomas (LaBCCs) require multi-disciplinary treatment including surgery, radiation, and systemic therapy. There is limited real-world data on patterns for these tumors. A multicenter retrospective chart review was performed of all laBCCs. Tumors were included if they underwent surgery (amputation, exenteration, bone resection, auriculectomy, excision the face scalp > 4 cm2), radiotherapy, or Data achievement no evidence disease (NED) poor outcomes (including local recurrence, nodal metastasis, distant disease-specific death) collected. Cox proportional Hazard modelling utilized to evaluate impact number treatments required clear tumor outcomes. total 494 laBCCs identified, which 414 (84%) achieved NED within first three lines treatment. 89 (21%) tumors developed a outcome. 363 (73%) received 84 (17%) 47 (10%) therapy as line 323 (65%) that treatment, 78 (48%) second 13 (33%) third NED. more likely develop compared only (HR:2.03, 95% CI: (1.3-3.3)). LaBCCs twice outcome Further studies are needed validate results.